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ENaC regulation by phospholipids and DGK explained through mathematical modeling

Cystic fibrosis is a condition caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). It is also thought to increase the activity of epithelial sodium channels (ENaC). The altered function of these ion channels is one of the causes of the thick dehydrated mucus that c...

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Detalles Bibliográficos
Autores principales: Olivença, Daniel V., Voit, Eberhard O., Pinto, Francisco R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435262/
https://www.ncbi.nlm.nih.gov/pubmed/32811866
http://dx.doi.org/10.1038/s41598-020-70630-w