A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity

BACKGROUND: AKT, a critical effector of the phosphoinositide 3-kinase (PI3K) signalling cascade, is an intensely pursued therapeutic target in oncology. Two distinct classes of AKT inhibitors have been in clinical development, ATP-competitive and allosteric. Class-specific differences in drug activi...

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Detalles Bibliográficos
Autores principales: Kostaras, Eleftherios, Kaserer, Teresa, Lazaro, Glorianne, Heuss, Sara Farrah, Hussain, Aasia, Casado, Pedro, Hayes, Angela, Yandim, Cihangir, Palaskas, Nicolaos, Yu, Yi, Schwartz, Brian, Raynaud, Florence, Chung, Yuen-Li, Cutillas, Pedro R., Vivanco, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435276/
https://www.ncbi.nlm.nih.gov/pubmed/32439931
http://dx.doi.org/10.1038/s41416-020-0889-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435276/
https://www.ncbi.nlm.nih.gov/pubmed/32439931
http://dx.doi.org/10.1038/s41416-020-0889-4

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