In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics

Drug resistance is a core issue in cancer chemotherapy. A known folate antagonist, methotrexate (MTX) inhibits human dihydrofolate reductase (hDHFR), the enzyme responsible for the catalysis of 7,8-dihydrofolate reduction to 5,6,7,8-tetrahydrofolate, in biosynthesis and cell proliferation. Structura...

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Detalles Bibliográficos
Autores principales: Rana, Rabia Mukhtar, Rampogu, Shailima, Abid, Noman Bin, Zeb, Amir, Parate, Shraddha, Lee, Gihwan, Yoon, Sanghwa, Kim, Yumi, Kim, Donghwan, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435474/
https://www.ncbi.nlm.nih.gov/pubmed/32752079
http://dx.doi.org/10.3390/molecules25153510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435474/
https://www.ncbi.nlm.nih.gov/pubmed/32752079
http://dx.doi.org/10.3390/molecules25153510

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