Synthesis of α-Aminophosphonic Acid Derivatives Through the Addition of O- and S-Nucleophiles to 2H-Azirines and Their Antiproliferative Effect on A549 Human Lung Adenocarcinoma Cells

This work reports a straightforward regioselective synthetic methodology to prepare α-aminophosphine oxides and phosphonates through the addition of oxygen and sulfur nucleophiles to the C–N double bond of 2H-azirine derivatives. Determined by the nature of the nucleophile, different α-aminophosphor...

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Detalles Bibliográficos
Autores principales: Carramiñana, Victor, Ochoa de Retana, Ana M., Palacios, Francisco, de los Santos, Jesús M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435673/
https://www.ncbi.nlm.nih.gov/pubmed/32708018
http://dx.doi.org/10.3390/molecules25153332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435673/
https://www.ncbi.nlm.nih.gov/pubmed/32708018
http://dx.doi.org/10.3390/molecules25153332

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