Loss of Both CDKN2A and CDKN2B Allows for Centrosome Overduplication in Melanoma

Centrosomes duplicate only once in coordination with the DNA replication cycle and have an important role in segregating genetic material. In contrast, most cancer cells have centrosome aberrations, including supernumerary centrosomes, and this correlates with aneuploidy and genetic instability. The...

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Detalles Bibliográficos
Autores principales: Patel, Shyamal, Wilkinson, Christopher J., Sviderskaya, Elena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435684/
https://www.ncbi.nlm.nih.gov/pubmed/32067956
http://dx.doi.org/10.1016/j.jid.2020.01.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435684/
https://www.ncbi.nlm.nih.gov/pubmed/32067956
http://dx.doi.org/10.1016/j.jid.2020.01.024

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