Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics

Disruption of protein:protein interactions (PPIs) that regulate the function of voltage-gated Na(+) (Nav) channels leads to neural circuitry aberrations that have been implicated in numerous channelopathies. One example of this pathophysiology is mediated by dysfunction of the PPI between Nav1.6 and...

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Detalles Bibliográficos
Autores principales: Dvorak, Nolan M., Wadsworth, Paul A., Wang, Pingyuan, Chen, Haiying, Zhou, Jia, Laezza, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435778/
https://www.ncbi.nlm.nih.gov/pubmed/32722255
http://dx.doi.org/10.3390/molecules25153365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435778/
https://www.ncbi.nlm.nih.gov/pubmed/32722255
http://dx.doi.org/10.3390/molecules25153365

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