Towards the Inhibition of Protein–Protein Interactions (PPIs) in STAT3: Insights into a New Class of Benzothiadiazole Derivatives

Signal transducer and activator of transcription 3 (STAT3) is a validated anticancer target due to the relationship between its constitutive activation and malignant tumors. Through a virtual screening approach on the STAT3-SH2 domain, 5,6-dimethyl-1H,3H-2,1,3-benzothiadiazole-2,2-dioxide (1) was id...

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Detalles Bibliográficos
Autores principales: Mori, Matteo, Gilardoni, Ettore, Regazzoni, Luca, Pedretti, Alessandro, Colombo, Diego, Parkinson, Gary, Asai, Akira, Meneghetti, Fiorella, Villa, Stefania, Gelain, Arianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435819/
https://www.ncbi.nlm.nih.gov/pubmed/32752073
http://dx.doi.org/10.3390/molecules25153509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435819/
https://www.ncbi.nlm.nih.gov/pubmed/32752073
http://dx.doi.org/10.3390/molecules25153509

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