Structure-Based Virtual Screening, Synthesis and Biological Evaluation of Potential FAK-FAT Domain Inhibitors for Treatment of Metastatic Cancer

Focal adhesion kinase (FAK) is a tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. In cancer cells, FAK promotes the progression and metastasis of tumours. In this study, we used structure-based virtual screening to filter a library of more than 210K compou...

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Detalles Bibliográficos
Autores principales: Kandil, Sahar B., Jones, Samuel R., Smith, Sonia, Hiscox, Stephen E., Westwell, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435868/
https://www.ncbi.nlm.nih.gov/pubmed/32751931
http://dx.doi.org/10.3390/molecules25153488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435868/
https://www.ncbi.nlm.nih.gov/pubmed/32751931
http://dx.doi.org/10.3390/molecules25153488

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