Cargando…

Structure-Based Virtual Screening, Synthesis and Biological Evaluation of Potential FAK-FAT Domain Inhibitors for Treatment of Metastatic Cancer

Focal adhesion kinase (FAK) is a tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. In cancer cells, FAK promotes the progression and metastasis of tumours. In this study, we used structure-based virtual screening to filter a library of more than 210K compou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kandil, Sahar B., Jones, Samuel R., Smith, Sonia, Hiscox, Stephen E., Westwell, Andrew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435868/ https://www.ncbi.nlm.nih.gov/pubmed/32751931 http://dx.doi.org/10.3390/molecules25153488

Ejemplares similares

Synthesis and Biological Evaluation of Bicalutamide Analogues for the Potential Treatment of Prostate Cancer
por: Kandil, Sahar B., et al.
Publicado: (2020)

New Insights into FAK Phosphorylation Based on a FAT Domain-Defective Mutation
por: Fang, Xuqian, et al.
Publicado: (2014)

Structure-Based Virtual Screening and Biological Evaluation of Peptide Inhibitors for Polo-Box Domain
por: Yan, Fang, et al.
Publicado: (2019)

Virtual Screening, Synthesis and Biological Evaluation of Streptococcus mutans Mediated Biofilm Inhibitors
por: Atta, Lubna, et al.
Publicado: (2022)

Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs
por: Qin, Qiaohua, et al.
Publicado: (2022)

Virtual Screening, Synthesis, and Biological Evaluation of Some Carbohydrazide Derivatives as Potential DPP-IV Inhibitors
por: Jadhav, Prerana B., et al.
Publicado: (2022)

Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells
por: Kandil, Sahar, et al.
Publicado: (2016)

Phospholipid binding to the FAK catalytic domain impacts function
por: Hall, Jessica E., et al.
Publicado: (2017)

ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites
por: Kandil, Sahar, et al.
Publicado: (2016)

Design of inhibitors of the HIV-1 integrase core domain using virtual screening
por: Regon, Preetom, et al.
Publicado: (2014)

Virtual Screening and Biological Evaluation of Piperazine Derivatives as Human Acetylcholinesterase Inhibitors
por: Varadaraju, Kavitha Raj, et al.
Publicado: (2013)

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth
por: Kurenova, Elena, et al.
Publicado: (2013)

Synergism of FAK and ROS1 inhibitors in the treatment of CDH1-deficient cancers mediated by FAK-YAP signaling
por: Gao, Jiaming, et al.
Publicado: (2023)

Virtual Screening and Biological Evaluation of Inhibitors Targeting the XPA-ERCC1 Interaction
por: Barakat, Khaled H., et al.
Publicado: (2012)

The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer
por: Wymant, Jennifer M., et al.
Publicado: (2016)

The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction
por: Xu, Shutong, et al.
Publicado: (2018)

The Development of FAK Inhibitors: A Five-Year Update
por: Spallarossa, Andrea, et al.
Publicado: (2022)

Discovery of New α-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation
por: Liu, Shan-Kui, et al.
Publicado: (2021)

Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors
por: Lin, Tony Eight, et al.
Publicado: (2021)

Discovery of Chitin Deacetylase Inhibitors through Structure-Based Virtual Screening and Biological Assays
por: Liu, Yaodong, et al.
Publicado: (2022)

Virtual Screening and Biological Activity Evaluation of New Potent Inhibitors Targeting Hexokinase-II
por: Liu, Ruijuan, et al.
Publicado: (2022)

Synthesis and biological evaluation of novel (E)-N'-benzylidene hydrazides as novel c-Met inhibitors through fragment based virtual screening
por: Liang, Jing-wei, et al.
Publicado: (2020)

Backtracking on FAK
por: Leslie, Mitch
Publicado: (2008)

FAK monitoring
por: Metzmacher, K D
Publicado: (1974)

Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay
por: Li, Jian, et al.
Publicado: (2006)

Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signaling
por: Wan, Qiaoqiao, et al.
Publicado: (2017)

A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening
por: Abdelfatah, Sara, et al.
Publicado: (2018)

Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling
por: Hariono, Maywan, et al.
Publicado: (2019)

Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis
por: Chen, Chang, et al.
Publicado: (2017)

FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
por: Schaller, Michael D.
Publicado: (2004)

Activation of Endogenous FAK via Expression of Its Amino Terminal Domain in Xenopus Embryos
por: Petridou, Nicoletta I., et al.
Publicado: (2012)

Large-Scale Virtual Screening Against the MET Kinase Domain Identifies a New Putative Inhibitor Type
por: Bresso, Emmanuel, et al.
Publicado: (2020)

Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK–YAP Signaling
por: Zhang, Baoyuan, et al.
Publicado: (2021)

The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis
por: Golubovskaya, Vita M, et al.
Publicado: (2009)

SY-707, an ALK/FAK/IGF1R inhibitor, suppresses growth and metastasis of breast cancer cells: SY-707 is an ALK/FAK/IGF1R inhibitor
por: Liu, Ping, et al.
Publicado: (2022)

Design, Synthesis, and Potent Anticancer Activity of Novel Indole-Based Bcl-2 Inhibitors
por: Almehdi, Ahmed M., et al.
Publicado: (2023)

Pharmacophore and Virtual Screening of JAK3 inhibitors
por: Rajeswari, Murugesan, et al.
Publicado: (2014)

Funky FAK proliferation
por: Tuma, Rabiya S.
Publicado: (2006)

Deconstructing FAK function
por: Short, Ben
Publicado: (2010)

FAK application software
por: Pearce, P, et al.
Publicado: (1975)

Cannot write session to /tmp/vufind_sessions/sess_85iaflibavt1sql5pgmdj6f9gv