Cargando…

Novel d-Annulated Pentacyclic Steroids: Regioselective Synthesis and Biological Evaluation in Breast Cancer Cells

The acid-catalyzed cyclization of benzylidenes based on 16-dehydropregnenolone acetate (16-DPA) was studied. It was found that these compounds readily undergo regioselective interrupted Nazarov cyclization with trapping chloride ion and an efficient method of the synthesis of d-annulated pentacyclic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vorontsova, Svetlana K., Yadykov, Anton V., Scherbakov, Alexander M., Minyaev, Mikhail E., Zavarzin, Igor V., Mikhaevich, Ekaterina I., Volkova, Yulia A., Shirinian, Valerii Z.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435891/ https://www.ncbi.nlm.nih.gov/pubmed/32752019 http://dx.doi.org/10.3390/molecules25153499

Ejemplares similares

Novel pentacyclic derivatives and benzylidenes of the progesterone series cause anti-estrogenic and antiproliferative effects and induce apoptosis in breast cancer cells
por: Scherbakov, Alexander M., et al.
Publicado: (2023)

Steroidal Pyrimidines and Dihydrotriazines as Novel Classes of Anticancer Agents against Hormone-Dependent Breast Cancer Cells
por: Scherbakov, Alexander M., et al.
Publicado: (2018)

Photochromic diarylethene ligands featuring 2-(imidazol-2-yl)pyridine coordination site and their iron(II) complexes
por: Lvov, Andrey G, et al.
Publicado: (2019)

Synthesis of Phosphorus(V)-Substituted Six-Membered N-Heterocycles: Recent Progress and Challenges
por: Volkova, Yulia, et al.
Publicado: (2023)

Honokiol inhibits the growth of hormone-resistant breast cancer cells: its promising effect in combination with metformin
por: Mikhaevich, Ekaterina I., et al.
Publicado: (2023)

Electrooxidation enables highly regioselective dearomative annulation of indole and benzofuran derivatives
por: Liu, Kun, et al.
Publicado: (2020)

Regioselective/electro-oxidative intermolecular [3 + 2] annulation for the preparation of indolines
por: Wang, Qingqing, et al.
Publicado: (2020)

Efficient Regioselective Synthesis of Novel Condensed Sulfur–Nitrogen Heterocyclic Compounds Based on Annulation Reactions of 2-Quinolinesulfenyl Halides with Alkenes and Cycloalkenes
por: Potapov, Vladimir A., et al.
Publicado: (2021)

Gold(I)-Catalyzed Synthesis of 3-Sulfenyl Pyrroles and Indoles by a Regioselective Annulation of Alkynyl Thioethers
por: Simm, Peter E., et al.
Publicado: (2021)

Highly regioselective and diastereodivergent aminomethylative annulation of dienyl alcohols enabled by a hydrogen-bonding assisting effect
por: Huang, Yao, et al.
Publicado: (2022)

Design, development and applications of copper-catalyzed regioselective (4 + 2) annulations between diaryliodonium salts and alkynes
por: Wang, Weilin, et al.
Publicado: (2022)

Substituent-Controllable Cascade Regioselective Annulation of β-Enaminones with N-Sulfonyl Triazoles for Modular Access to Imidazoles and Pyrroles
por: Wang, Hua, et al.
Publicado: (2023)

Efficient Regioselective Synthesis of Novel Water-Soluble 2H,3H-[1,4]thiazino[2,3,4-ij]quinolin-4-ium Derivatives by Annulation Reactions of 8-quinolinesulfenyl Halides
por: Potapov, Vladimir A., et al.
Publicado: (2021)

Exosomes are involved in the intercellular transfer of rapamycin resistance in the breast cancer cells
por: Shchegolev, Yuri Yu., et al.
Publicado: (2023)

Carbonyl-assisted reverse regioselective cascade annulation of 2-acetylenic ketones triggered by Ru-catalyzed C–H activation
por: Gollapelli, Krishna Kumar, et al.
Publicado: (2016)

Catalyst-controlled regioselectivity in phosphine catalysis: the synthesis of spirocyclic benzofuranones via regiodivergent [3 + 2] annulations of aurones and an allenoate
por: Ni, Huanzhen, et al.
Publicado: (2017)

Regioselectivity of the S(E)Ar-based cyclizations and S(E)Ar-terminated annulations of 3,5-unsubstituted, 4-substituted indoles
por: Das, Jonali, et al.
Publicado: (2022)

How mono- and diphosphine ligands alter regioselectivity of the Rh-catalyzed annulative cleavage of bicyclo[1.1.0]butanes
por: Chen, Pan-Pan, et al.
Publicado: (2022)

Towards Unravelling the Role of ERα-Targeting miRNAs in the Exosome-Mediated Transferring of the Hormone Resistance
por: Andreeva, Olga E., et al.
Publicado: (2021)

Targeting hormone-resistant breast cancer cells with docetaxel: a look inside the resistance
por: Scherbakov, Alexander M., et al.
Publicado: (2023)

Bioinspired synthesis of pentacyclic onocerane triterpenoids
por: Bartels, Florian, et al.
Publicado: (2017)

Theoretical Investigations on the Rh(III)-Catalyzed Oxidative C–H Activation/Annulation of Salicylaldehydes with Masked Enynes: Mechanism Insights and Regioselectivity Origins
por: Xiang, Xin, et al.
Publicado: (2023)

Secretion of Mutant DNA and mRNA by the Exosomes of Breast Cancer Cells
por: Andreeva, Olga E., et al.
Publicado: (2021)

Regioselective synthesis of spirocyclic pyrrolines via a palladium-catalyzed Narasaka–Heck/C–H activation/[4 + 2] annulation cascade reaction
por: Wei, Wan-Xu, et al.
Publicado: (2022)

Inhibition of Human Neutrophil Elastase by Pentacyclic Triterpenes
por: Feng, Li, et al.
Publicado: (2013)

Nanoformulations for Delivery of Pentacyclic Triterpenoids in Anticancer Therapies
por: Kaps, Anna, et al.
Publicado: (2021)

[3+2] regioselective annulation reaction of 2-arylidene-1,3-indandiones towards synthesis of spirocyclopentenes: understanding the mechanism of γ-attack vs. α-attack using DFT studies
por: Anwar, Shaik, et al.
Publicado: (2021)

Rh(iii)-catalyzed regioselective C–H activation dialkenylation/annulation cascade for rapid access to 6H-isoindolo[2,1-a]indole
por: Zhang, Fangming, et al.
Publicado: (2021)

Pentacyclic Triterpenes in Euphorbia microsciadia with Their T-cell Proliferation Activity
por: Ayatollahi, Abdul Majid, et al.
Publicado: (2011)

Inhibitory effects and actions of pentacyclic triterpenes upon glycation
por: Yin, Mei-Chin
Publicado: (2015)

Bioactive Pentacyclic Triterpenes from the Stems of Combretum laxum
por: Bisoli, Eder, et al.
Publicado: (2008)

Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies
por: J. C. Furtado, Niege A., et al.
Publicado: (2017)

EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy
por: Ciftci, Halil I., et al.
Publicado: (2021)

Regioselective addition/annulation of ferrocenyl thioamides with 1,3-diynes via a sulfur-transfer rearrangement to construct extended π-conjugated ferrocenes with luminescent properties
por: Yan, Lipeng, et al.
Publicado: (2020)

p-Type Conjugated Polymers Containing Electron-Deficient Pentacyclic Azepinedione
por: He, Qiao, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Pentacyclic Strychnos Alkaloids as Selective Modulators of the ABCC10 (MRP7) Efflux Pump
por: Teijaro, Christiana N., et al.
Publicado: (2014)

Metal-free C–H arylation of imidazoheterocycles with aryl hydrazines
por: Jana, Sourav, et al.
Publicado: (2018)

Supercritical Fluid Chromatography—Tandem Mass Spectrometry for Rapid Quantification of Pentacyclic Triterpenoids in Plant Extracts
por: Falev, Danil I., et al.
Publicado: (2022)

Annulate lamellae: comparison of antigenic epitopes of annulate lamellae membranes with the nuclear envelope
Publicado: (1988)

Annulation of 1H-pyrrole-2,3-diones by thioacetamide: an approach to 5-azaisatins
por: Kobelev, Aleksandr I, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6id2081k55rrpchv8ubdkapctg