Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1

Two novel structural types of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors with hexahydroisobenzofuran 11 and 3-oxabicyclo [3.3.1]nonane 12 scaffolds were discovered. These monoterpene-derived compounds were synthesized through preliminary isomerization of (+)-3-carene to (+)-2-carene followed...

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Detalles Bibliográficos
Autores principales: Il’ina, Irina V., Dyrkheeva, Nadezhda S., Zakharenko, Alexandra L., Sidorenko, Alexander Yu., Li-Zhulanov, Nikolay S., Korchagina, Dina V., Chand, Raina, Ayine-Tora, Daniel M., Chepanova, Arina A., Zakharova, Olga D., Ilina, Ekaterina S., Reynisson, Jóhannes, Malakhova, Anastasia A., Medvedev, Sergey P., Zakian, Suren M., Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436013/
https://www.ncbi.nlm.nih.gov/pubmed/32751997
http://dx.doi.org/10.3390/molecules25153496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436013/
https://www.ncbi.nlm.nih.gov/pubmed/32751997
http://dx.doi.org/10.3390/molecules25153496

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