Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition

O-GlcNAcylation is an essential post-translational modification that occurs on nuclear and cytoplasmic proteins, regulating their function in response to cellular stress and altered nutrient availability. O-GlcNAc transferase (OGT) is the enzyme that catalyzes this reaction and represents a potentia...

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Detalles Bibliográficos
Autores principales: Loi, Elena Maria, Weiss, Matjaž, Pajk, Stane, Gobec, Martina, Tomašič, Tihomir, Pieters, Roland J., Anderluh, Marko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436030/
https://www.ncbi.nlm.nih.gov/pubmed/32722493
http://dx.doi.org/10.3390/molecules25153381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436030/
https://www.ncbi.nlm.nih.gov/pubmed/32722493
http://dx.doi.org/10.3390/molecules25153381

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