(19)F NMR‐Based Fragment Screening for 14 Different Biologically Active RNAs and 10 DNA and Protein Counter‐Screens

We report here the nuclear magnetic resonance (19)F screening of 14 RNA targets with different secondary and tertiary structure to systematically assess the druggability of RNAs. Our RNA targets include representative bacterial riboswitches that naturally bind with nanomolar affinity and high specif...

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Detalles Bibliográficos
Autores principales: Binas, Oliver, de Jesus, Vanessa, Landgraf, Tom, Völklein, Albrecht Eduard, Martins, Jason, Hymon, Daniel, Kaur Bains, Jasleen, Berg, Hannes, Biedenbänder, Thomas, Fürtig, Boris, Lakshmi Gande, Santosh, Niesteruk, Anna, Oxenfarth, Andreas, Shahin Qureshi, Nusrat, Schamber, Tatjana, Schnieders, Robbin, Tröster, Alix, Wacker, Anna, Wirmer‐Bartoschek, Julia, Wirtz Martin, Maria Alexandra, Stirnal, Elke, Azzaoui, Kamal, Richter, Christian, Sreeramulu, Sridhar, José Blommers, Marcel Jules, Schwalbe, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436455/
https://www.ncbi.nlm.nih.gov/pubmed/32794266
http://dx.doi.org/10.1002/cbic.202000476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436455/
https://www.ncbi.nlm.nih.gov/pubmed/32794266
http://dx.doi.org/10.1002/cbic.202000476

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