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The Enzyme‐Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid

Phosphoramidates composed of an amino acid and a nucleotide analogue are critical metabolites of prodrugs, such as remdesivir. Hydrolysis of the phosphoramidate liberates the nucleotide, which can then be phosphorylated to become the pharmacologically active triphosphate. Enzymatic hydrolysis has be...

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Detalles Bibliográficos
Autores principales: Jovanovic, Dejana, Tremmel, Peter, Pallan, Pradeep S., Egli, Martin, Richert, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436718/
https://www.ncbi.nlm.nih.gov/pubmed/32757352
http://dx.doi.org/10.1002/anie.202008665