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CRISPR and transposon in vivo screens for cancer drivers and therapeutic targets
Human cancers harbor substantial genetic, epigenetic, and transcriptional changes, only some of which drive oncogenesis at certain times during cancer evolution. Identifying the cancer-driver alterations amongst the vast swathes of “passenger” changes still remains a major challenge. Transposon and...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437018/ https://www.ncbi.nlm.nih.gov/pubmed/32811551 http://dx.doi.org/10.1186/s13059-020-02118-9 |