RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. While pathogenic mutations in the DNA/RNA-binding protein Matrin-3 (MATR3) are linked to ALS and distal myopathy, the molecular mecha...

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Detalles Bibliográficos
Autores principales: Ramesh, Nandini, Kour, Sukhleen, Anderson, Eric N., Rajasundaram, Dhivyaa, Pandey, Udai Bhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437177/
https://www.ncbi.nlm.nih.gov/pubmed/32811564
http://dx.doi.org/10.1186/s40478-020-01021-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437177/
https://www.ncbi.nlm.nih.gov/pubmed/32811564
http://dx.doi.org/10.1186/s40478-020-01021-5

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