Resveratrol corrects aberrant splicing of RYR1 pre-mRNA and Ca(2+) signal in myotonic dystrophy type 1 myotubes

Myotonic dystrophy type 1 (DM1) is a spliceopathy related to the mis-splicing of several genes caused by sequestration of nuclear transcriptional RNA-binding factors from non-coding CUG repeats of DMPK pre-mRNAs. Dysregulation of ryanodine receptor 1 (RYR1), sarcoplasmatic/endoplasmatic Ca(2+)-ATPas...

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Detalles Bibliográficos
Autores principales: Santoro, Massimo, Piacentini, Roberto, Perna, Alessia, Pisano, Eugenia, Severino, Anna, Modoni, Anna, Grassi, Claudio, Silvestri, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437583/
https://www.ncbi.nlm.nih.gov/pubmed/32209783
http://dx.doi.org/10.4103/1673-5374.276336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437583/
https://www.ncbi.nlm.nih.gov/pubmed/32209783
http://dx.doi.org/10.4103/1673-5374.276336

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