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Resveratrol corrects aberrant splicing of RYR1 pre-mRNA and Ca(2+) signal in myotonic dystrophy type 1 myotubes

Myotonic dystrophy type 1 (DM1) is a spliceopathy related to the mis-splicing of several genes caused by sequestration of nuclear transcriptional RNA-binding factors from non-coding CUG repeats of DMPK pre-mRNAs. Dysregulation of ryanodine receptor 1 (RYR1), sarcoplasmatic/endoplasmatic Ca(2+)-ATPas...

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Detalles Bibliográficos
Autores principales:	Santoro, Massimo, Piacentini, Roberto, Perna, Alessia, Pisano, Eugenia, Severino, Anna, Modoni, Anna, Grassi, Claudio, Silvestri, Gabriella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437583/ https://www.ncbi.nlm.nih.gov/pubmed/32209783 http://dx.doi.org/10.4103/1673-5374.276336

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