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Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model
INTRODUCTION: Metformin can accumulate and cause lactic acidosis in patients with renal insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by proximal tubules indirectly requires energy. We investigated whether addition of metformin before or during ex vivo...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437879/ https://www.ncbi.nlm.nih.gov/pubmed/32816871 http://dx.doi.org/10.1136/bmjdrc-2019-000816 |