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Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model

INTRODUCTION: Metformin can accumulate and cause lactic acidosis in patients with renal insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by proximal tubules indirectly requires energy. We investigated whether addition of metformin before or during ex vivo...

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Detalles Bibliográficos
Autores principales:	Posma, Rene A, Venema, Leonie H, Huijink, Tobias M, Westerkamp, Andrie C, Wessels, A Mireille A, De Vries, Nynke J, Doesburg, Frank, Roggeveld, J, Ottens, Petra J, Touw, Daan J, Nijsten, Maarten W, Leuvenink, Henri G D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Emerging Technologies, Pharmacology and Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437879/ https://www.ncbi.nlm.nih.gov/pubmed/32816871 http://dx.doi.org/10.1136/bmjdrc-2019-000816

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