Design of Stapled Antimicrobial Peptides that Overcome Antibiotic Resistance and In Vivo Toxicity

The clinical translation of cationic alpha-helical antimicrobial peptides (AMPs) has been hindered by structural instability, proteolytic degradation, and in vivo toxicity from non-specific membrane lysis. Although analyses of hydrophobic content and charge distribution have informed the design of s...

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Detalles Bibliográficos
Autores principales: Mourtada, Rida, Herce, Henry D., Yin, Daniel J., Moroco, Jamie A., Wales, Thomas E., Engen, John R., Walensky, Loren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437984/
https://www.ncbi.nlm.nih.gov/pubmed/31427820
http://dx.doi.org/10.1038/s41587-019-0222-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437984/
https://www.ncbi.nlm.nih.gov/pubmed/31427820
http://dx.doi.org/10.1038/s41587-019-0222-z

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