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Design of Stapled Antimicrobial Peptides that Overcome Antibiotic Resistance and In Vivo Toxicity
The clinical translation of cationic alpha-helical antimicrobial peptides (AMPs) has been hindered by structural instability, proteolytic degradation, and in vivo toxicity from non-specific membrane lysis. Although analyses of hydrophobic content and charge distribution have informed the design of s...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437984/ https://www.ncbi.nlm.nih.gov/pubmed/31427820 http://dx.doi.org/10.1038/s41587-019-0222-z |