Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology

Lipotoxic cardiomyopathy (LCM) is characterized by cardiac steatosis, including the accumulation of fatty acids, triglycerides and ceramides. Model systems have shown the inhibition of ceramide biosynthesis to antagonize obesity and improve insulin sensitivity. Sphingosine Δ4 desaturase (encoded by...

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Detalles Bibliográficos
Autores principales: Walls, Stanley M., Chatfield, Dale A., Ocorr, Karen, Harris, Greg L., Bodmer, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438009/
https://www.ncbi.nlm.nih.gov/pubmed/32641420
http://dx.doi.org/10.1242/dmm.043083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438009/
https://www.ncbi.nlm.nih.gov/pubmed/32641420
http://dx.doi.org/10.1242/dmm.043083

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