Actomyosin contractility confers mechanoprotection against TNFα-induced disruption of the intervertebral disc

Inflammation triggers degradation of intervertebral disc extracellular matrix (ECM), a hallmark of disc degeneration that contributes to back pain. Mechanosensitive nucleus pulposus cells are responsible for ECM production, yet the impact of a proinflammatory microenvironment on cell mechanobiology...

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Detalles Bibliográficos
Autores principales: Hernandez, Paula A., Jacobsen, Timothy D., Chahine, Nadeen O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438088/
https://www.ncbi.nlm.nih.gov/pubmed/32875103
http://dx.doi.org/10.1126/sciadv.aba2368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438088/
https://www.ncbi.nlm.nih.gov/pubmed/32875103
http://dx.doi.org/10.1126/sciadv.aba2368

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