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A series of helical α-synuclein fibril polymorphs are populated in the presence of lipid vesicles
α-Synuclein (αS) deposition is a defining characteristic of Parkinson’s disease (PD) pathology, and other synucleinopathies. αS aggregates in disease, leading to the generation of neuronal inclusions known as Lewy bodies. These accumulate in the cytoplasmic space of dopaminergic neurons in the subst...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438318/ https://www.ncbi.nlm.nih.gov/pubmed/32864427 http://dx.doi.org/10.1038/s41531-020-00122-1 |