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A novel naphthalimide that selectively targets breast cancer via the arylhydrocarbon receptor pathway

We report that the naphthalimide analogue 2-(2-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (NAP-6) is a highly potent and selective breast cancer targeting molecule. These effects are mediated via the aryl hydrocarbon receptor (AHR) pathway and the subsequent induction of CYP1 metabolising m...

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Detalles Bibliográficos
Autores principales: Gilbert, J., De Iuliis, G. N., McCluskey, A., Sakoff, J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438328/
https://www.ncbi.nlm.nih.gov/pubmed/32814815
http://dx.doi.org/10.1038/s41598-020-70597-8