Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor

Glycine is one of the major neurotransmitters in the brainstem and the spinal cord. Glycine binds to and activates glycine receptors (GlyRs), increasing Cl(−) conductance at postsynaptic sites. This glycinergic synaptic transmission contributes to the generation of respiratory rhythm and motor patte...

Descripción completa

Detalles Bibliográficos
Autores principales: Ito, Daishi, Kawazoe, Yoshinori, Sato, Ayato, Uesugi, Motonari, Hirata, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438329/
https://www.ncbi.nlm.nih.gov/pubmed/32814817
http://dx.doi.org/10.1038/s41598-020-70983-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438329/
https://www.ncbi.nlm.nih.gov/pubmed/32814817
http://dx.doi.org/10.1038/s41598-020-70983-2

Ejemplares similares