Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in prostate cancer (PCa) is undefined. Here we show that DOT1L is overexpressed in PCa and is associated with poor outcome. Genetic an...

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Detalles Bibliográficos
Autores principales: Vatapalli, R., Sagar, V., Rodriguez, Y., Zhao, J. C., Unno, K., Pamarthy, S., Lysy, B., Anker, J., Han, H., Yoo, Y. A., Truica, M., Chalmers, Z. R., Giles, F., Yu, J., Chakravarti, D., Carneiro, B., Abdulkadir, S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438336/
https://www.ncbi.nlm.nih.gov/pubmed/32814769
http://dx.doi.org/10.1038/s41467-020-18013-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438336/
https://www.ncbi.nlm.nih.gov/pubmed/32814769
http://dx.doi.org/10.1038/s41467-020-18013-7

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