Neurotoxicity of HIV-1 Tat is attributed to its penetrating property

We have recently engineered an exosomal Tat (Exo-Tat) which can activate latent HIV-1 in resting CD4+ T lymphocytes from antiretroviral treated HIV-1 infected patients. HIV-1 Tat protein can penetrate cell membrane freely and secrete into extracellular medium. Exo-Tat loses this penetrating property...

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Detalles Bibliográficos
Autores principales: Tang, Xiaoli, Lu, Huafei, Ramratnam, Bharat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438513/
https://www.ncbi.nlm.nih.gov/pubmed/32814783
http://dx.doi.org/10.1038/s41598-020-70950-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438513/
https://www.ncbi.nlm.nih.gov/pubmed/32814783
http://dx.doi.org/10.1038/s41598-020-70950-x

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