Cargando…

Neurotoxicity of HIV-1 Tat is attributed to its penetrating property

We have recently engineered an exosomal Tat (Exo-Tat) which can activate latent HIV-1 in resting CD4+ T lymphocytes from antiretroviral treated HIV-1 infected patients. HIV-1 Tat protein can penetrate cell membrane freely and secrete into extracellular medium. Exo-Tat loses this penetrating property...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Xiaoli, Lu, Huafei, Ramratnam, Bharat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438513/ https://www.ncbi.nlm.nih.gov/pubmed/32814783 http://dx.doi.org/10.1038/s41598-020-70950-x

Ejemplares similares

Impact of exosomal HIV-1 Tat expression on the human cellular proteome
por: Lu, Huafei, et al.
Publicado: (2019)

Role of endolysosomes in HIV-1 Tat-induced neurotoxicity
por: Hui, Liang, et al.
Publicado: (2012)

Oxidative Stress Is Associated with Neuroinflammation in Animal Models of HIV-1 Tat Neurotoxicity
por: Louboutin, Jean-Pierre, et al.
Publicado: (2014)

The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein
por: Torkzaban, Bahareh, et al.
Publicado: (2020)

Anti-tat Hutat2:Fc mediated protection against tat-induced neurotoxicity and HIV-1 replication in human monocyte-derived macrophages
por: Kang, Wen, et al.
Publicado: (2014)

Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity
por: Natarajaseenivasan, Kalimuthusamy, et al.
Publicado: (2018)

Iron Saturation Drives Lactoferrin Effects on Oxidative Stress and Neurotoxicity Induced by HIV-1 Tat
por: Ianiro, Giusi, et al.
Publicado: (2023)

HIV-1 Tat Protein Increases Microglial Outward K(+) Current and Resultant Neurotoxic Activity
por: Liu, Jianuo, et al.
Publicado: (2013)

Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization
por: Tang, Xiaoli, et al.
Publicado: (2010)

HIV-Tat protein and amyloid β peptide form multifibrillar structures that cause neurotoxicity
por: Hategan, Alina, et al.
Publicado: (2017)

Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein
por: Charnay, Nicolas, et al.
Publicado: (2009)

A monoclonal antibody against HIV Tat attenuates neurotoxicity via glutamate receptors
por: Rumbaugh, Jeffrey, et al.
Publicado: (2006)

Correction: HIV-1 Tat Protein Increases Microglial Outward K(+) Current and Resultant Neurotoxic Activity
Publicado: (2014)

Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects
por: Paris, Jason J., et al.
Publicado: (2020)

Human immunodeficiency virus-1 Tat exerts its neurotoxic effects by downregulating Sonic hedgehog signaling
por: khan, Irfan A., et al.
Publicado: (2022)

Glycogen Synthase Kinase 3 Beta (GSK3β) Phosphorylates the RNAase III Enzyme Drosha at S300 and S302
por: Tang, Xiaoli, et al.
Publicado: (2011)

Penetration of HIV-1 Tat(47–57) into PC/PE Bilayers Assessed by MD Simulation and X-ray Scattering
por: Neale, Chris, et al.
Publicado: (2015)

Suppression of HIV and cocaine-induced neurotoxicity and inflammation by cell penetrable itaconate esters
por: Cui, B. Celia, et al.
Publicado: (2023)

HIV-1 Tat and T cell apoptosis
por: Krammer, Peter H
Publicado: (2006)

HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear
por: D’Orso, Iván, et al.
Publicado: (2010)

Acetylation of Drosha on the N-Terminus Inhibits Its Degradation by Ubiquitination
por: Tang, Xiaoli, et al.
Publicado: (2013)

Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells
por: Turner, John J., et al.
Publicado: (2005)

Conjugation to the Cell-Penetrating Peptide TAT Potentiates the Photodynamic Effect of Carboxytetramethylrhodamine
por: Srinivasan, Divyamani, et al.
Publicado: (2011)

Opiate Addiction Therapies and HIV-1 Tat: Interactive Effects on Glial [Ca(2+)]i, Oxyradical and Neuroinflammatory Chemokine Production and Correlative Neurotoxicity
por: Fitting, Sylvia, et al.
Publicado: (2014)

1Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA
por: Krishnan, Gopinath, et al.
Publicado: (2015)

HIV-1 Tat: Role in Bystander Toxicity
por: Ajasin, David, et al.
Publicado: (2020)

Proteomic characterization of HIV-1 Tat interactome
por: Gautier, VW, et al.
Publicado: (2006)

Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat
por: Egelé, Caroline, et al.
Publicado: (2008)

Dynamic interactions of the HIV-1 Tat with nucleic acids are critical for Tat activity in reverse transcription
por: Boudier, Christian, et al.
Publicado: (2014)

Targeting Multidrug-resistant Staphylococci with an anti-rpoA Peptide Nucleic Acid Conjugated to the HIV-1 TAT Cell Penetrating Peptide
por: Abushahba, Mostafa FN, et al.
Publicado: (2016)

Two‐pore channels regulate Tat endolysosome escape and Tat‐mediated HIV‐1 LTR transactivation
por: Khan, Nabab, et al.
Publicado: (2020)

HIV-1 Tat interacts with LIS1 protein
por: Epie, Nicolas, et al.
Publicado: (2005)

Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription
por: Ammosova, Tatyana, et al.
Publicado: (2006)

Recruitment and Activation of RSK2 by HIV-1 Tat
por: Hetzer, Claudia, et al.
Publicado: (2007)

Impact of Tat Genetic Variation on HIV-1 Disease
por: Li, Luna, et al.
Publicado: (2012)

Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides
por: Turner, John J., et al.
Publicado: (2005)

Infection by CXCR4-Tropic Human Immunodeficiency Virus Type 1 Is Inhibited by the Cationic Cell-Penetrating Peptide Derived from HIV-1 Tat
por: Keogan, Shawn, et al.
Publicado: (2012)

Tat-SF1 Is Not Required for Tat Transactivation but Does Regulate the Relative Levels of Unspliced and Spliced HIV-1 RNAs
por: Miller, Heather B., et al.
Publicado: (2009)

The role of HIV Tat protein in HIV-related cardiovascular diseases
por: Jiang, Yanan, et al.
Publicado: (2018)

HEXIM1-Tat chimera inhibits HIV-1 replication
por: Leoz, Marie, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nij7rlcsbo23u4qnnio6inlgv0