Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming

Arginine auxotrophy due to the silencing of argininosuccinate synthetase 1 (ASS1) occurs in many carcinomas and in the majority of sarcomas. Arginine deiminase (ADI-PEG20) therapy exploits this metabolic vulnerability by depleting extracellular arginine, causing arginine starvation. ASS1-negative ce...

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Detalles Bibliográficos
Autores principales: Brashears, Caitlyn B., Barlin, Meltem, Ehrhardt, William R., Rathore, Richa, Schultze, Matthew, Tzeng, Shin-Chen, Van Tine, Brian A., Held, Jason M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438517/
https://www.ncbi.nlm.nih.gov/pubmed/32814773
http://dx.doi.org/10.1038/s41419-020-02899-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438517/
https://www.ncbi.nlm.nih.gov/pubmed/32814773
http://dx.doi.org/10.1038/s41419-020-02899-8

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