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Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics

Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly mutated in hereditary spastic paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To investigate how the physiological roles of the ER might be affected by such disrup...

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Detalles Bibliográficos
Autores principales: Oliva, Megan K., Pérez-Moreno, Juan José, O’Shaughnessy, Jillian, Wardill, Trevor J., O’Kane, Cahir J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438849/
https://www.ncbi.nlm.nih.gov/pubmed/32903680
http://dx.doi.org/10.3389/fnins.2020.00816