Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity

Local anesthetics (LAs), such as lidocaine and mexiletine, inhibit bronchoconstriction in asthmatics, but adverse effects limit their use for this specific clinical application. In this study, we describe the anti-spasmodic properties of the mexiletine analog 2-(2-aminopropoxy)-3,5-dimethyl, 4-Br-be...

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Detalles Bibliográficos
Autores principales: Carvalho, Katharinne Ingrid Moraes, Coutinho, Diego de Sá, Joca, Humberto Cavalcante, Miranda, Artur Santos, Cruz, Jader dos Santos, Silva, Emerson Teixeira, Souza, Marcus Vinícius Nora, Faria, Robson Xavier, Silva, Patricia Machado Rodrigues e, Costa, Jorge Carlos Santos, Martins, Marco Aurélio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438868/
https://www.ncbi.nlm.nih.gov/pubmed/32903732
http://dx.doi.org/10.3389/fphar.2020.01159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438868/
https://www.ncbi.nlm.nih.gov/pubmed/32903732
http://dx.doi.org/10.3389/fphar.2020.01159

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