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Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?
TRPM2 is a non-selective, Ca(2+)-permeable cation channel widely expressed in immune cells. It is firmly established that the channel can be activated by intracellular adenosine 5′-diphosphoribose (ADPR). Until recent cryo-EM structures have exhibited an additional nucleotide binding site in the N-t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438885/ https://www.ncbi.nlm.nih.gov/pubmed/32903769 http://dx.doi.org/10.3389/fimmu.2020.02018 |