Cargando…

Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?

TRPM2 is a non-selective, Ca(2+)-permeable cation channel widely expressed in immune cells. It is firmly established that the channel can be activated by intracellular adenosine 5′-diphosphoribose (ADPR). Until recent cryo-EM structures have exhibited an additional nucleotide binding site in the N-t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fliegert, Ralf, Riekehr, Winnie M., Guse, Andreas H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438885/ https://www.ncbi.nlm.nih.gov/pubmed/32903769 http://dx.doi.org/10.3389/fimmu.2020.02018

Ejemplares similares

cADPR Does Not Activate TRPM2
por: Riekehr, Winnie Maria, et al.
Publicado: (2022)

Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn “southern” ribose conformation underlies activity at the sea urchin cADPR receptor
por: Moreau, Christelle, et al.
Publicado: (2011)

Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
por: Huang, Xiangchen, et al.
Publicado: (2010)

Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2
por: Baszczyňski, Ondřej, et al.
Publicado: (2019)

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR)
por: Baszczyňski, Ondřej, et al.
Publicado: (2020)

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349
por: Fliegert, Ralf, et al.
Publicado: (2017)

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca(2+) Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation
por: Gul, Rukhsana, et al.
Publicado: (2016)

Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications
por: Zhou, Yue, et al.
Publicado: (2012)

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist
por: Kirchberger, Tanja, et al.
Publicado: (2009)

A novel mechanism of imeglimin‐mediated insulin secretion via the cADPR‐TRP channel pathway
por: Funazaki, Shunsuke, et al.
Publicado: (2021)

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms
por: Deshpande, Deepak A., et al.
Publicado: (2018)

cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel
por: Höke, Ahmet
Publicado: (2022)

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers
por: Watt, Joanna M., et al.
Publicado: (2018)

Synthesis of cyclic N(1)-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells
por: Mahal, Ahmed, et al.
Publicado: (2015)

Sarm1 activation produces cADPR to increase intra-axonal Ca(++) and promote axon degeneration in PIPN
por: Li, Yihang, et al.
Publicado: (2021)

Selective inhibition of TRPM2 channel by two novel synthesized ADPR analogues
por: Luo, Xiao, et al.
Publicado: (2017)

Inhibition of Cardiomyocytes Differentiation of Mouse Embryonic Stem Cells by CD38/cADPR/Ca(2+) Signaling Pathway
por: Wei, Wen-Jie, et al.
Publicado: (2012)

ADP-Ribose and oxidative stress activate TRPM8 channel in prostate cancer and kidney cells
por: Baş, Ercan, et al.
Publicado: (2019)

Design and Synthesis of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose, a Calcium Ion-Mobilizing Second Messenger**
por: Tsuzuki, Takayoshi, et al.
Publicado: (2013)

4-Thioribose Analogues of Adenosine Diphosphate Ribose (ADPr) Peptides
por: Madern, Jerre M., et al.
Publicado: (2023)

Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR
por: Kühn, Frank J. P., et al.
Publicado: (2019)

A Cell Permeable NPE Caged ADP-Ribose for Studying TRPM2
por: Yu, Peilin, et al.
Publicado: (2012)

Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca(2+)-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets
por: Park, Dae-Ryoung, et al.
Publicado: (2015)

Synthesis of the Ca(2+)-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling
por: Lin, Wee K., et al.
Publicado: (2017)

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain
por: Kühn, Frank J. P., et al.
Publicado: (2016)

Pancreatic β-Cell Death, Regeneration and Insulin Secretion: Roles of Poly(ADP-Ribose) Polymerase and Cyclic ADP-Ribose
por: Takasawa, Shin, et al.
Publicado: (2002)

Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling
por: Ernst, Insa M. A., et al.
Publicado: (2013)

Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2
por: Yu, Peilin, et al.
Publicado: (2017)

Molecular Bases of Catalysis and ADP-Ribose Preference of Human Mn(2+)-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase and Conversion by Mutagenesis to a Preferential Cyclic ADP-Ribose Phosphohydrolase
por: Cabezas, Alicia, et al.
Publicado: (2015)

Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase
por: Ribeiro, João Meireles, et al.
Publicado: (2018)

Spatio-temporal propagation of Ca(2+) signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors
por: Bruzzone, Santina, et al.
Publicado: (2003)

Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice
por: Zhong, Jing, et al.
Publicado: (2016)

Requirement for the N-Terminal Coiled-Coil Domain for Expression and Function, but not Subunit Interaction of, the ADPR-Activated TRPM2 Channel
por: Mei, Zhu-Zhong, et al.
Publicado: (2009)

Trpm2 Ablation Accelerates Protein Aggregation by Impaired ADPR and Autophagic Clearance in the Brain
por: Jang, Yongwoo, et al.
Publicado: (2018)

Switch-like compaction of poly(ADP-ribose) upon cation binding
por: Badiee, Mohsen, et al.
Publicado: (2023)

‘Click cyclic ADP-ribose’: a neutral second messenger mimic
por: Swarbrick, Joanna M., et al.
Publicado: (2014)

Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation
por: Schwarz, Nicole, et al.
Publicado: (2012)

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate
por: Tóth, Balázs, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs
por: D’Errico, Stefano, et al.
Publicado: (2018)

Structure–Activity Relationship of Adenosine 5′-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) Channel: Rational Design of Antagonists
por: Moreau, Christelle, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_90rkqh4s92bn4rvm8ku6ap8ith