Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning

Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored in invasion and metastasis. Here, we investigated heterogeneity within collective cancer invasion by integrating DNA methylation and gene expression analysis in rare purified...

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Detalles Bibliográficos
Autores principales: Summerbell, Emily R., Mouw, Janna K., Bell, Joshua S. K., Knippler, Christina M., Pedro, Brian, Arnst, Jamie L., Khatib, Tala O., Commander, Rachel, Barwick, Benjamin G., Konen, Jessica, Dwivedi, Bhakti, Seby, Sandra, Kowalski, Jeanne, Vertino, Paula M., Marcus, Adam I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439406/
https://www.ncbi.nlm.nih.gov/pubmed/32832657
http://dx.doi.org/10.1126/sciadv.aaz6197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439406/
https://www.ncbi.nlm.nih.gov/pubmed/32832657
http://dx.doi.org/10.1126/sciadv.aaz6197

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