Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor

Allosteric communication within proteins is a hallmark of biochemical signaling, but the dynamic transmission pathways remain poorly characterized. We combined NMR spectroscopy and surface plasmon resonance to reveal these pathways and quantify their energetics in the glucocorticoid receptor, a tran...

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Detalles Bibliográficos
Autores principales: Köhler, C., Carlström, G., Gunnarsson, A., Weininger, U., Tångefjord, S., Ullah, V., Lepistö, M., Karlsson, U., Papavoine, T., Edman, K., Akke, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439413/
https://www.ncbi.nlm.nih.gov/pubmed/32832645
http://dx.doi.org/10.1126/sciadv.abb5277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439413/
https://www.ncbi.nlm.nih.gov/pubmed/32832645
http://dx.doi.org/10.1126/sciadv.abb5277

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