Structure-specific DNA recombination sites: Design, validation, and machine learning–based refinement

Recombination systems are widely used as bioengineering tools, but their sites have to be highly similar to a consensus sequence or to each other. To develop a recombination system free of these constraints, we turned toward attC sites from the bacterial integron system: single-stranded DNA hairpins...

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Detalles Bibliográficos
Autores principales: Nivina, Aleksandra, Grieb, Maj Svea, Loot, Céline, Bikard, David, Cury, Jean, Shehata, Laila, Bernardes, Juliana, Mazel, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439510/
https://www.ncbi.nlm.nih.gov/pubmed/32832653
http://dx.doi.org/10.1126/sciadv.aay2922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439510/
https://www.ncbi.nlm.nih.gov/pubmed/32832653
http://dx.doi.org/10.1126/sciadv.aay2922

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