ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression

Mutations in genes encoding SWI/SNF chromatin remodeling complexes are found in approximately 20% of all human cancers, with ARID1A being the most frequently mutated subunit. Here, we show that disruption of ARID1A homologs in a zebrafish model accelerates the onset and increases the penetrance of M...

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Detalles Bibliográficos
Autores principales: Shi, Hui, Tao, Ting, Abraham, Brian J., Durbin, Adam D., Zimmerman, Mark W., Kadoch, Cigall, Look, A. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439613/
https://www.ncbi.nlm.nih.gov/pubmed/32832616
http://dx.doi.org/10.1126/sciadv.aaz3440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439613/
https://www.ncbi.nlm.nih.gov/pubmed/32832616
http://dx.doi.org/10.1126/sciadv.aaz3440

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