Nonspecific Heme-Binding Cyclase, AbmU, Catalyzes [4 + 2] Cycloaddition during Neoabyssomicin Biosynthesis

[Image: see text] Diels–Alder (DA) [4 + 2]-cycloaddition reactions rank among the most powerful transformations in synthetic organic chemistry; biosynthetic examples, however, are few and far between. We report here a heme-binding cyclase, AbmU, that catalyzes an essential [4 + 2] cycloaddition duri...

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Detalles Bibliográficos
Autores principales: Li, Qinglian, Ding, Wenjuan, Tu, Jiajia, Chi, Changbiao, Huang, Hongbo, Ji, Xiaoqi, Yao, Ziwei, Ma, Ming, Ju, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439702/
https://www.ncbi.nlm.nih.gov/pubmed/32832808
http://dx.doi.org/10.1021/acsomega.0c02776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439702/
https://www.ncbi.nlm.nih.gov/pubmed/32832808
http://dx.doi.org/10.1021/acsomega.0c02776

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