ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity

The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants' analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in...

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Detalles Bibliográficos
Autores principales: Ali, Fedaa, Elserafy, Menattallah, Alkordi, Mohamed H., Amin, Muhamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439997/
https://www.ncbi.nlm.nih.gov/pubmed/32844124
http://dx.doi.org/10.1016/j.bbrep.2020.100798
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author Ali, Fedaa
Elserafy, Menattallah
Alkordi, Mohamed H.
Amin, Muhamed
author_facet Ali, Fedaa
Elserafy, Menattallah
Alkordi, Mohamed H.
Amin, Muhamed
author_sort Ali, Fedaa
collection PubMed
description The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants' analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively.
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spelling pubmed-74399972020-08-21 ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity Ali, Fedaa Elserafy, Menattallah Alkordi, Mohamed H. Amin, Muhamed Biochem Biophys Rep Research Article The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants' analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively. Elsevier 2020-08-20 /pmc/articles/PMC7439997/ /pubmed/32844124 http://dx.doi.org/10.1016/j.bbrep.2020.100798 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Ali, Fedaa
Elserafy, Menattallah
Alkordi, Mohamed H.
Amin, Muhamed
ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity
title ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity
title_full ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity
title_fullStr ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity
title_full_unstemmed ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity
title_short ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity
title_sort ace2 coding variants in different populations and their potential impact on sars-cov-2 binding affinity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439997/
https://www.ncbi.nlm.nih.gov/pubmed/32844124
http://dx.doi.org/10.1016/j.bbrep.2020.100798
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