Cargando…

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

T regulatory (Treg) cells play vital roles in modulating immunity and tissue homeostasis. Their actions depend on TCR recognition of peptide-MHC molecules; yet the degree of peptide specificity of Treg-cell function, and whether Treg ligands can be used to manipulate Treg cell biology are unknown. H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernandes, Ricardo A, Li, Chaoran, Wang, Gang, Yang, Xinbo, Savvides, Christina S, Glassman, Caleb R, Dong, Shen, Luxenberg, Eric, Sibener, Leah V, Birnbaum, Michael E, Benoist, Christophe, Mathis, Diane, Garcia, K Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440915/ https://www.ncbi.nlm.nih.gov/pubmed/32773038 http://dx.doi.org/10.7554/eLife.58463

Ejemplares similares

IL18 signaling promotes homing of mature Tregs into the thymus
por: Peligero-Cruz, Cristina, et al.
Publicado: (2020)

Structure of the IL-27 quaternary receptor signaling complex
por: Caveney, Nathanael A, et al.
Publicado: (2022)

Imbalance of Th22/Treg cells causes microinflammation in uremic patients undergoing hemodialysis
por: Ren, Tingting, et al.
Publicado: (2019)

ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation
por: Tian, Miaomiao, et al.
Publicado: (2021)

Loss of GTPase activating protein neurofibromin stimulates paracrine cell communication via macropinocytosis
por: Ghoshal, Pushpankur, et al.
Publicado: (2019)

Developmental and cellular age direct conversion of CD4(+) T cells into RORγ(+) or Helios(+) colon Treg cells
por: Pratama, Alvin, et al.
Publicado: (2019)

A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding
por: Huisman, Brooke D, et al.
Publicado: (2022)

Discovery of Renal Tuberculosis in a Partial Nephrectomy Specimen Done for Renal Tumor
por: Saadi, Ahmed, et al.
Publicado: (2015)

The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia–reperfusion brain injury in mice
por: Hammarlund, Maria E., et al.
Publicado: (2021)

Incidental discovery of an interstitial emphysematous cystitis with liver abscess: A report of hematogenous spread of infection
por: Rajih, Emad, et al.
Publicado: (2020)

Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq
por: Vazquez, Sara E, et al.
Publicado: (2022)

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells
por: van Santen, Hisse-Martien, et al.
Publicado: (2004)

Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4(+) and CD8(+) T-lymphocytes
por: Moshfegh, C.M., et al.
Publicado: (2019)

Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction
por: Godo, Shigeo, et al.
Publicado: (2021)

Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials
por: Lorenzatti, Alberto J
Publicado: (2021)

Atherosclerotic Cardiovascular Disease in Rheumatoid Arthritis: Impact of Inflammation and Antirheumatic Treatment
por: Kerola, Anne Mirjam, et al.
Publicado: (2021)

The Role of C-reactive Protein in Patient Risk Stratification and Treatment
por: Arroyo-Espliguero, Ramón, et al.
Publicado: (2021)

Inflammation and Cardiovascular Disease: The Future
por: Arnold, Natalie, et al.
Publicado: (2021)

Small bowel stomas are associated with higher risk of circulating food-specific-IgG than patients with organic gastrointestinal conditions and colostomies
por: Carson, Walker K, et al.
Publicado: (2022)

Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin
por: Zarin, Payam, et al.
Publicado: (2023)

Mutations from patients with IPEX ported to mice reveal different patterns of FoxP3 and Treg dysfunction
por: Leon, Juliette, et al.
Publicado: (2023)

Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity
por: Mendoza, Juan L, et al.
Publicado: (2020)

Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice
por: Ryu, Seungjin, et al.
Publicado: (2021)

Cytokine and metabolic regulation of adipose tissue Tregs
por: Elkins, Cody, et al.
Publicado: (2022)

Metabolism Score for Visceral Fat (METS-VF): A New Predictive Surrogate for CKD Risk
por: Feng, Ling, et al.
Publicado: (2022)

Perinatal granulopoiesis and risk of pediatric asthma
por: Turturice, Benjamin A, et al.
Publicado: (2021)

Penile necrosis and calciphylaxis
por: Gomes Torres, José Henrique, et al.
Publicado: (2021)

Surrogate explanations for role discovery on graphs
por: Cunningham, Eoghan, et al.
Publicado: (2023)

Profound Treg perturbations correlate with COVID-19 severity
por: Galván-Peña, Silvia, et al.
Publicado: (2021)

DNA damage independent inhibition of NF-κB transcription by anthracyclines
por: Chora, Angelo Ferreira, et al.
Publicado: (2022)

Establishment of a concept of visceral fat syndrome and discovery of adiponectin
por: Matsuzawa, Yuji
Publicado: (2010)

A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?
por: Benoist, Christophe, et al.
Publicado: (2000)

Surrogate cytokine agonists: promising agents against COVID-19
por: Lin, Zemin, et al.
Publicado: (2022)

Waist to hip ratio and trunk to extremity fat (DXA) are better surrogates for IMCL and for visceral fat respectively than for subcutaneous fat in adolescent girls
por: Savgan-Gurol, Eray, et al.
Publicado: (2010)

Central obesity as a clinical marker of adiposopathy; increased visceral adiposity as a surrogate marker for global fat dysfunction
por: Bays, Harold
Publicado: (2014)

Surrogate Wnt agonists that phenocopy canonical Wnt/β-catenin signaling
por: Janda, Claudia Y., et al.
Publicado: (2017)

Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists
por: Ajram, Laura, et al.
Publicado: (2014)

Paediatric autoimmune encephalopathies: clinical features, laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigens
por: Hacohen, Yael, et al.
Publicado: (2013)

Clinical relevance of positive voltage-gated potassium channel (VGKC)-complex antibodies: experience from a tertiary referral centre
por: Paterson, Ross W, et al.
Publicado: (2013)

Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype
por: Mathey, Emily K, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_tr6hem409i9temaecb60bdo8hl