Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

The chloride-proton exchanger CLC-7 plays critical roles in lysosomal homeostasis and bone regeneration and its mutation can lead to osteopetrosis, lysosomal storage disease and neurological disorders. In lysosomes and the ruffled border of osteoclasts, CLC-7 requires a β-subunit, OSTM1, for stabili...

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Detalles Bibliográficos
Autores principales: Schrecker, Marina, Korobenko, Julia, Hite, Richard K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440919/
https://www.ncbi.nlm.nih.gov/pubmed/32749217
http://dx.doi.org/10.7554/eLife.59555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440919/
https://www.ncbi.nlm.nih.gov/pubmed/32749217
http://dx.doi.org/10.7554/eLife.59555

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