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The RECQL helicase prevents replication fork collapse during replication stress
Most tumors lack the G1/S phase checkpoint and are insensitive to antigrowth signals. Loss of G1/S control can severely perturb DNA replication as revealed by slow replication fork progression and frequent replication fork stalling. Cancer cells may thus rely on specific pathways that mitigate the d...
Autores principales: | Benedict, Bente, van Bueren, Marit AE, van Gemert, Frank PA, Lieftink, Cor, Guerrero Llobet, Sergi, van Vugt, Marcel ATM, Beijersbergen, Roderick L, te Riele, Hein |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441523/ https://www.ncbi.nlm.nih.gov/pubmed/32820027 http://dx.doi.org/10.26508/lsa.202000668 |
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