DNA polymerase stalling at structured DNA constrains the expansion of short tandem repeats

BACKGROUND: Short tandem repeats (STRs) contribute significantly to de novo mutagenesis, driving phenotypic diversity and genetic disease. Although highly diverse, their repetitive sequences induce DNA polymerase slippage and stalling, leading to length and sequence variation. However, current studi...

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Detalles Bibliográficos
Autores principales: Murat, Pierre, Guilbaud, Guillaume, Sale, Julian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441554/
https://www.ncbi.nlm.nih.gov/pubmed/32819438
http://dx.doi.org/10.1186/s13059-020-02124-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441554/
https://www.ncbi.nlm.nih.gov/pubmed/32819438
http://dx.doi.org/10.1186/s13059-020-02124-x

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