Cargando…

DNA polymerase stalling at structured DNA constrains the expansion of short tandem repeats

BACKGROUND: Short tandem repeats (STRs) contribute significantly to de novo mutagenesis, driving phenotypic diversity and genetic disease. Although highly diverse, their repetitive sequences induce DNA polymerase slippage and stalling, leading to length and sequence variation. However, current studi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murat, Pierre, Guilbaud, Guillaume, Sale, Julian E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441554/ https://www.ncbi.nlm.nih.gov/pubmed/32819438 http://dx.doi.org/10.1186/s13059-020-02124-x

Ejemplares similares

Mechanism of RNA polymerase II stalling by DNA alkylation
por: Malvezzi, Stefano, et al.
Publicado: (2017)

Stalling of Eukaryotic Translesion DNA Polymerases at DNA-Protein Cross-Links
por: Yudkina, Anna V., et al.
Publicado: (2022)

Tandem-genotypes: robust detection of tandem repeat expansions from long DNA reads
por: Mitsuhashi, Satomi, et al.
Publicado: (2019)

Analysis of Short Tandem Repeats by Parallel DNA Threading
por: Zajac, Pawel, et al.
Publicado: (2009)

Pathogenic CANVAS (AAGGG)(n) repeats stall DNA replication due to the formation of alternative DNA structures
por: Hisey, Julia A., et al.
Publicado: (2023)

DNA Fingerprinting: Use of Autosomal Short Tandem Repeats in Forensic DNA Typing
por: Keerti, Akshunna, et al.
Publicado: (2022)

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ
por: Hirota, Kouji, et al.
Publicado: (2015)

Determination of human DNA replication origin position and efficiency reveals principles of initiation zone organisation
por: Guilbaud, Guillaume, et al.
Publicado: (2022)

STRetch: detecting and discovering pathogenic short tandem repeat expansions
por: Dashnow, Harriet, et al.
Publicado: (2018)

Linked-read sequencing for detecting short tandem repeat expansions
por: Chiu, Readman, et al.
Publicado: (2022)

Phosphorylated Rad18 directs DNA Polymerase η to sites of stalled replication
por: Day, Tovah A., et al.
Publicado: (2010)

DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation
por: Bétous, Rémy, et al.
Publicado: (2013)

In vivo evidence for translesion synthesis by the replicative DNA polymerase δ
por: Hirota, Kouji, et al.
Publicado: (2016)

DNA replication initiation shapes the mutational landscape and expression of the human genome
por: Murat, Pierre, et al.
Publicado: (2022)

Reverse Transcription Errors and RNA–DNA Differences at Short Tandem Repeats
por: Fungtammasan, Arkarachai, et al.
Publicado: (2016)

Rho-dependent transcription termination in bacteria recycles RNA polymerases stalled at DNA lesions
por: Jain, Sriyans, et al.
Publicado: (2019)

Short Tandem Repeat Expansions and RNA-Mediated Pathogenesis in Myotonic Dystrophy
por: Sznajder, Łukasz J., et al.
Publicado: (2019)

Efficient isothermal expansion of human telomeric and minisatellite repeats by Thermococcus litoralis DNA polymerase
por: Hartig, Jörg S., et al.
Publicado: (2005)

The RecQ DNA helicase Rqh1 constrains Exonuclease 1-dependent recombination at stalled replication forks
por: Osman, Fekret, et al.
Publicado: (2016)

Genome-wide detection of short tandem repeat expansions by long-read sequencing
por: Liu, Qian, et al.
Publicado: (2020)

Short tandem repeat expansions in sporadic amyotrophic lateral sclerosis and frontotemporal dementia
por: Henden, Lyndal, et al.
Publicado: (2023)

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II
por: van der Weegen, Yana, et al.
Publicado: (2020)

Tandemly repeated DNA families in the mouse genome
por: Komissarov, Aleksey S, et al.
Publicado: (2011)

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks
por: Yan, Shan, et al.
Publicado: (2009)

Genome-wide evaluation of the effect of short tandem repeat variation on local DNA methylation
por: Martin-Trujillo, Alejandro, et al.
Publicado: (2023)

Short Tandem Repeat (STR) Profiling of Earwax DNA Obtained from Healthy Volunteers
por: Amer, Sayed Amin, et al.
Publicado: (2023)

DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation
por: Lormand, Justin D., et al.
Publicado: (2013)

Degradation of DNA damage-independently stalled RNA polymerase II is independent of the E3 ligase Elc1
por: Karakasili, E., et al.
Publicado: (2015)

α,β-D-Constrained Nucleic Acids Are Strong Terminators of Thermostable DNA Polymerases in Polymerase Chain Reaction
por: Martínez, Olivier, et al.
Publicado: (2011)

Native functions of short tandem repeats
por: Wright, Shannon E, et al.
Publicado: (2023)

An Ultra-High Discrimination Y Chromosome Short Tandem Repeat Multiplex DNA Typing System
por: Hanson, Erin K., et al.
Publicado: (2007)

Forensic DNA Profiling: Autosomal Short Tandem Repeat as a Prominent Marker in Crime Investigation
por: Nwawuba Stanley, Udogadi, et al.
Publicado: (2020)

Case report: Using DNA short tandem repeats to confirm nongestational origin of pulmonary choriocarcinoma
por: da Silva, Filipa Ferreira, et al.
Publicado: (2022)

Genetic characteristics of spouse selection based on short tandem repeats in DNA and lunula count on fingertip
por: Xia, Qi, et al.
Publicado: (2023)

Short Tandem Repeat (STR) DNA Analysis for Using Coffee Cups As Forensic Medicine Evidence
por: Saeed, Abdullah, et al.
Publicado: (2023)

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes
por: Wanrooij, Sjoerd, et al.
Publicado: (2007)

Degradation of DNA damage-independently stalled RNA polymerase II is independent of the E3 ligase Elc1
por: Karakasili, Eleni, et al.
Publicado: (2014)

RNA polymerase pausing, stalling and bypass during transcription of damaged DNA: from molecular basis to functional consequences
por: Agapov, Aleksei, et al.
Publicado: (2022)

Publisher Correction: The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II
por: van der Weegen, Yana, et al.
Publicado: (2020)

DNA Repair and DNA Triplet Repeat Expansion: The Impact of Abasic Lesions on Triplet Repeat DNA Energetics
por: Völker, Jens, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_d4vs583bmoogacvf1q9vs3to30