Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome

BACKGROUND: Oral administration is the most common way to deliver drugs to the systemic circulation or target organs. Orally administered drugs are absorbed in the intestine and metabolized in the intestine and liver. In the early stages of drug development, it is important to predict first-pass met...

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Detalles Bibliográficos
Autores principales: Ohta, Yumi, Kazuki, Kanako, Abe, Satoshi, Oshimura, Mitsuo, Kobayashi, Kaoru, Kazuki, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441628/
https://www.ncbi.nlm.nih.gov/pubmed/32819341
http://dx.doi.org/10.1186/s12896-020-00637-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441628/
https://www.ncbi.nlm.nih.gov/pubmed/32819341
http://dx.doi.org/10.1186/s12896-020-00637-8

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