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Inhibition of voltage-gated Na(+) currents by eleclazine in rat atrial and ventricular myocytes
BACKGROUND: Atrial-ventricular differences in voltage-gated Na(+) currents might be exploited for atrial-selective antiarrhythmic drug action for the suppression of atrial fibrillation without risk of ventricular tachyarrhythmia. Eleclazine (GS-6615) is a putative antiarrhythmic drug with properties...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442036/ https://www.ncbi.nlm.nih.gov/pubmed/32864638 http://dx.doi.org/10.1016/j.hroo.2020.05.006 |