Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

Identification of targeted therapies for TNBC is an urgent medical need. Using a drug combination screen reliant on synthetic lethal interactions, we identified clinically relevant combination therapies for different TNBC subtypes. Two drug combinations targeting the BET family were further explored...

Descripción completa

Detalles Bibliográficos
Autores principales: Verma, Nandini, Vinik, Yaron, Saroha, Ashish, Nair, Nishanth Ulhas, Ruppin, Eytan, Mills, Gordon, Karn, Thomas, Dubey, Vinay, Khera, Lohit, Raj, Harsha, Maina, Flavio, Lev, Sima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442484/
https://www.ncbi.nlm.nih.gov/pubmed/32937365
http://dx.doi.org/10.1126/sciadv.aba8968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442484/
https://www.ncbi.nlm.nih.gov/pubmed/32937365
http://dx.doi.org/10.1126/sciadv.aba8968

Ejemplares similares