Cargando…

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

Identification of targeted therapies for TNBC is an urgent medical need. Using a drug combination screen reliant on synthetic lethal interactions, we identified clinically relevant combination therapies for different TNBC subtypes. Two drug combinations targeting the BET family were further explored...

Descripción completa

Detalles Bibliográficos
Autores principales:	Verma, Nandini, Vinik, Yaron, Saroha, Ashish, Nair, Nishanth Ulhas, Ruppin, Eytan, Mills, Gordon, Karn, Thomas, Dubey, Vinay, Khera, Lohit, Raj, Harsha, Maina, Flavio, Lev, Sima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442484/ https://www.ncbi.nlm.nih.gov/pubmed/32937365 http://dx.doi.org/10.1126/sciadv.aba8968

Ejemplares similares

The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC
por: Khera, Lohit, et al.
Publicado: (2021)

PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein
por: Kedan, Amir, et al.
Publicado: (2018)

Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity
por: Cheng, Kuoyuan, et al.
Publicado: (2021)

BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators
por: Castellanet, Olivier, et al.
Publicado: (2021)

Synthetic lethality-based prediction of anti-SARS-CoV-2 targets
por: Pal, Lipika R., et al.
Publicado: (2021)

Synthetic lethality-based prediction of anti-SARS-CoV-2 targets
por: Pal, Lipika R., et al.
Publicado: (2022)

Moving ahead on harnessing synthetic lethality to fight cancer
por: Jerby-Arnon, Livnat, et al.
Publicado: (2015)

Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells
por: Consoli, Valeria, et al.
Publicado: (2022)

Mouse Modeling Dissecting Macrophage–Breast Cancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment and Breast Tumorigenesis
por: Müller, Anna‐Katharina, et al.
Publicado: (2022)

A new BET on the control of HIV latency
por: Karn, Jonathan
Publicado: (2013)

Putative functional genes in idiopathic dilated cardiomyopathy
por: Nair, Nishanth Ulhas, et al.
Publicado: (2018)

The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice
por: Shatz-Azoulay, Hadas, et al.
Publicado: (2020)

Genome‐scale metabolic modeling reveals SARS‐CoV‐2‐induced metabolic changes and antiviral targets
por: Cheng, Kuoyuan, et al.
Publicado: (2021)

Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets
por: Cheng, Kuoyuan, et al.
Publicado: (2021)

Overview of Ferroptosis and Synthetic Lethality Strategies
por: Kinowaki, Yuko, et al.
Publicado: (2021)

Cross-species identification of cancer resistance–associated genes that may mediate human cancer risk
por: Nair, Nishanth Ulhas, et al.
Publicado: (2022)

Modeling Heterogeneity of Triple‐Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance
por: Lamballe, Fabienne, et al.
Publicado: (2020)

Chemotherapy with ceramide in TNBC
por: Legembre, Patrick, et al.
Publicado: (2015)

GHRH-antagonists in TNBC
por: Engel, Jörg B.
Publicado: (2015)

Cripto-1 in TNBC
por: Castro, Nadia P, et al.
Publicado: (2015)

BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma
por: Ishida, Chiaki Tsuge, et al.
Publicado: (2017)

Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets
por: Vann, Kendra R., et al.
Publicado: (2020)

The Landscape of Targeted Therapies in TNBC
por: Vagia, Elena, et al.
Publicado: (2020)

Neural Functions Play Different Roles in Triple Negative Breast Cancer (TNBC) and non-TNBC
por: Tan, Renbo, et al.
Publicado: (2020)

OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells
por: Baquero, Juan Miguel, et al.
Publicado: (2022)

Differential effect on different immune subsets of neoadjuvant chemotherapy in patients with TNBC
por: Massa, Chiara, et al.
Publicado: (2020)

Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response
por: Vinik, Yaron, et al.
Publicado: (2020)

To Bet or Not to Bet on T-bet As a Therapeutic Target in Emphysema?
por: Wang, Xiaoyun, et al.
Publicado: (2019)

The Evaluation of Cytotoxic Properties from CCB-2 Sugar Complexes Against TNBC and Non-TNBC Cells
por: Jenie, Riris Istighfari, et al.
Publicado: (2021)

BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition
por: Meng, Yu, et al.
Publicado: (2023)

TNBC invasion: downstream of STAT3
por: Jackson, James G., et al.
Publicado: (2017)

Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues
por: Crawford, David R., et al.
Publicado: (2022)

Analyzing Gene Expression from Whole Tissue vs. Different Cell Types Reveals the Central Role of Neurons in Predicting Severity of Alzheimer’s Disease
por: Stempler, Shiri, et al.
Publicado: (2012)

Correction: Analyzing Gene Expression from Whole Tissue vs. Different Cell Types Reveals the Central Role of Neurons in Predicting Severity of Alzheimer’s Disease
por: Stempler, Shiri, et al.
Publicado: (2012)

The Potential of PSMA as a Vascular Target in TNBC
por: Heesch, Amelie, et al.
Publicado: (2023)

Aptamer-Based Strategies to Boost Immunotherapy in TNBC
por: Agnello, Lisa, et al.
Publicado: (2023)

Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology
por: Chaudhuri, Aiswarya, et al.
Publicado: (2023)

Lifetime Prediction of Polymers: To Bet, or Not to Bet—Is This the Question?
por: Blanco, Ignazio
Publicado: (2018)

Anticancer Effect of Benzimidazole Derivatives, Especially Mebendazole, on Triple-Negative Breast Cancer (TNBC) and Radiotherapy-Resistant TNBC In Vivo and In Vitro
por: Choi, Hoon Sik, et al.
Publicado: (2021)

Genomic and transcriptomic analyses identify a prognostic gene signature and predict response to therapy in pleural and peritoneal mesothelioma
por: Nair, Nishanth Ulhas, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7tdeh4jb3odoemjbr2dc8o1tg1